@article{302,
  keywords = {neonatal lung disease, mechanical ventilation, infants, continuous positive airway pressure, closed-loop oxygen control},
  author = {Michael Urschitz and Werner Horn and Andreas Seyfang and Antonella Hallenberger and T. Herberts and Silvia Miksch and Christian Popow and Ingo Mueller-Hansen and Christian Poets},
  title = {{Automatic Control of the Inspired Oxygen Fraction in Preterm Infants, A Randomized Cross-over Trial}},
  abstract = {In preterm infants receiving supplemental oxygen, manual control of the inspired oxygen fraction is often time-consuming and inappropriate. We developed a system for automatic oxygen control and hypothesized that this system is more effective than routine manual oxygen control in maintaining target arterial oxygen saturation levels. We performed a randomized controlled crossover clinical trial in 12 preterm infants receiving nasal continuous positive airway pressure and supplemental oxygen. Periods with automatic and routine manual oxygen control were compared with periods of optimal control by a fully dedicated person. The median (range) percentage of time with arterial oxygen saturation levels within target range (87–96%) was 81.7% (39.0–99.8) for routine manual oxygen control, 91.0% (41.4–99.3) for optimal control, and 90.5% (59.0–99.4) for automatic control (ANOVA: p = 0.01). Pairwise post hoc comparisons revealed a statistically significant difference between automatic and routine manual oxygen control (Dunnett&#39;s test: p = 0.02). The frequency of manual oxygen adjustments was lowest in automatic control (Friedman&#39;s test: p < 0.001). Automatic oxygen control may optimize oxygen administration to preterm infants receiving nasal continuous positive airway pressure and reduce nursing time spent with oxygen control. Key Words: closed-loop oxygen control * continuous positive airway pressure * infants * mechanical ventilation * neonatal lung disease
},
  year = {2004},
  journal = {American Journal Respiratory and Critical Care Medicine (AJRCCM)},
  volume = {10},
  pages = {170},
  url = {http://ajrccm.atsjournals.org/cgi/content/full/170/10/1095},
  doi = {pdf gesperrt},
  note = {scientific award, place number one, Society of Neonatology and Pediatric Intensive Care Gesellschaft für Neonatologie und Prädiatrische Intensivmedizin (GNPI 2005)
},
  language = {eng},
}